Selected Current Research Projects

• Development of Osteoarthritis in Transgenic Mice with Increased SAF-1 Expression in Articular Cartilage: We will test in mice whether the over-production of serum amyloid-A activating factor-1 (SAF-1) in articular cartilage cells will lead to the spontaneous development of osteoarthritis, compared to non-transgenic control animals. Under normal conditions, cartilage dynamically remodels itself, with a balance of enzymes. But in osteoarthritis, certain enzymes are over-expressed, leading to a net loss of collagen and cartilage deterioration . An understanding of how these complex molecular processes work may help us better treat – or even prevent – the onset of osteoarthritis.
• Comparison of Tissue-Engineered Osteochondral Grafts Fabricated with Mesenchymal Stem Cells and Bioactive Glass or Allograft Bone: Tissue engineering of cartilage and bone with cells harvested from the host is an experimental approach that could offer a therapeutic alternative to the clinical options presently used to treat deficient and diseased cartilage in human joints. This investigation is designed to fabricate tissue-engineered osteochondral grafts and examine them after transplantation into the weight-bearing joint of a live-animal model. To determine the effect of the subchondral support material on graft function in rabbits, we are studying various types of osteochondral grafts, made from allograft bone, bioactive glass, trabecular metal, and ceramic composites, respectively. Our goal is to evaluate whether any of these materials may lead to the development of a practical solution for the loss of articular cartilage.
• Development of Ceramic-Polyethylene Bearings, and Functional Gradient Materials for Hip and Knee Replacement Bearings: To eliminate the need for bone cement, and the possibility of metal ion release in the body, we are developing a new class of orthopaedic bearings using porous alumina ceramic and polyethylene. Our work will result in more durable bearings that can service the needs of younger and active patients. Separately, we are investigating novel manufacturing methods for ceramic bearings that will result in composite materials with superior wear properties, and extreme fracture toughness.

Dr. Cook was part of a team that performed a hip replacement for the University’s most unusual patient: Pasha, a snow leopard that suffered from osteoarthritis. Teamwork between researchers in medicine, veterinary medicine, engineering, and other disciplines is helping better understand how to treat hip and knee problems in humans.

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