James L. Cook, DVM, PhD
William C. Allen Endowed Scholar for Orthopaedic Research
Director, Comparative Orthopaedic Laboratory

Clinical Interests:

Veterinary – arthroscopy, minimally invasive surgery, canine sports medicine

Research Interests:

Osteoarthritis, Meniscal and Articular Cartilage Tissue Engineering

Board Certification:

Diplomate of the American College of Veterinary Surgeons, 1999

Education:

BS, Florida State University, Tallahassee, FL, 1988
DVM, University of Missouri, Columbia, MO 1994
PhD, University of Missouri, Columbia, MO 1998
Residency, University of Missouri, Columbia, MO

Honors, Awards, Recognitions:

• Pfizer Award for Research Excellence. 2004.

• Mark S. Bloomberg Lecturer, International Canine Sports Medicine Symposium. 2004.

• ORS New Investigator Recognition Award. 2003.

• Brinker Lecturer, Michigan Veterinary Conference. 2003.

• Golden Chalk Award. Graduate Professional Council, University of Missouri. 2001.

• Hohn-Johnson Research Award. Veterinary Orthopedic Society. 2001.

• Norden Distinguished Teacher Award. 2000.

• Mark S. Bloomberg Memorial Resident Research Award. 1996.

Patents and FDA approvals:
Canine Total Elbow Arthroplasty System. University of Missouri, Columbia, MO. Cook JL and Lower J. (Pending, 2005).

SIS Meniscal Implant (G040072). Depuy Orthopaedics/DePuy Biologics, Inc., Warsaw, IN/Raynham, MA. Approved November 10, 2004.

Selected Publications:

1. Lima EG, Chao G, Vunjak-Novakovic G, Ateshian GA, Cook JL, and Hung CT. The effect of devitalized trabecular bone on the formation of osteochondral tissue-engineered constructs. Biomaterials 2008; in press.
2. Bian L, Lima EG, Angione SL, Ng KW, Williams DY, Xu D, Stoker AM, Cook JL, Ateshian GA, and Hung CT.  Mechanical and biochemical characterization of cartilage explants in serum-free culture. J Biomech 2008;41:1153-1159.
3. Cook JL, Cook CR. Bilateral shoulder and elbow arthroscopy in dogs with forelimb lameness: Diagnostic findings and treatment outcomes. Vet Surg 2008; in press.
4. Stoker AM, Guastella DB, Kuroki K, and Cook JL. Evaluation of chondroprotective nutriceuticals in an in vitro osteoarthritis model. Osteoarthritis and Cartilage 2008; in press.
5. Cook JL, Hudson CT, Kuroki K. Autogenous osteochondral grafting for treatment of stifle osteochondrosis in dogs. Vet Surg 2008; in press.
6. Cook JL, Fox DB, Kuroki K, Jayo M, DeDeyne PG. In vitro and in vivo comparison of five biomaterials used for orthopedic soft tissue augmentation. Am J Vet Res 2008;69:148-156.
7. Venable RO, Stoker AM, Cook CR, Cockrell M, and Cook JL. Examination of synovial fluid hyaluronan as a potential biomarker for osteoarthritis in the stifle of dogs. Am J Vet Res 2008; in press.
8. Dismukes DI, Fox DB, Tomlinson JL, Cook JL, Essman SC. Determination of pelvic limb alignment in the large-breed dog: a cadaveric radiographic study in the frontal plane. Vet Surg 2008; in press.
9. Guastella DB, Fox DB, Cook JL.  Tibial plateau angle in four common canine breeds with cranial cruciate ligament rupture and its relationship to meniscal tears. Vet Comp Orthop Traumatol 2008;21:125-128.
10. Dismukes DI, Tomlinson JL, Fox DB, Cook JL, Witsberger TH. Radiographic measurement of canine tibial angles in the sagittal plane. Vet Surg 2008;37:300-305
11. Cogar SM, Cook CR, Curry SL, Grandis A, and Cook JL. Prospective evaluation of techniques for differentiating shoulder pathology as a source of forelimb lameness in medium and large breed dogs. Vet Surg 2008;37:132-141.
12. Witsberger TH, Villamil A, Schultz LG, Hahn AW, and Cook JL. Prevalence of and risk factors for hip dysplasia and cranial cruciate ligament deficiency in dogs. J Am Vet Med Assoc 2008;232:1818-8124.
13. Cook JL, Fox DB. A novel bioabsorbable conduit augments healing of avascular meniscal tears in a dog model. Am J Sports Med 2007;35:1877-1887.
14. Cook JL, Kuroki K, Stoker AM, Streppa HK, Fox DB. Review of in vitro models and development and initial validation of a novel co-culture model for the study of osteoarthritis. Curr Rev Rheumatol 2007;3:172-182.
15. Luther JK, Cook CR, Constantinescu IA, Cook JL, Constantinescu GM. Clinical and anatomical correlations of the canine meniscus. J Exp Med Surg Res 2007;14:5-14.
16. DePuy T, Howard R, Keegan K, Wilson D, Kramer J, Cook JL, Childers MK. Effects of intra-articular botulinum toxin type A in an equine model of acute synovitis: a pilot study. Am J Phys Med Rehabil 2007;86:777-783.
17. Dismukes DI, Tomlinson JL, Fox DB, Cook JL, Song KJE. Radiographic measurement of the proximal and distal mechanical joint angles in the canine tibia. Vet Surg 2007;36:699-704.
18. Tomlinson JL, Fox DB, Cook JL, Keller GG. Measurement of femoral angles in four dog breeds. Vet Surg 2007;36:593-598.
19. Cook JL. Outcomes based patient care in veterinary surgery: What is an outcome measure? Vet Surg 2007;36:187-189/
20. Crow BD, Haltom JD, Carson WL, Greene WB, and Cook JL. Evaluation of a novel biomaterial for intrasubstance muscle laceration repair. J Orthop Res 2007;25:396-403.
21. Witsberger TH, Cook JL, Cook CR. What is your diagnosis? (Coxofemoral luxation with pseudoarthrosis and orthotopic bone formation in a dog). J Am Vet Med Assoc 2007;230:1631-1632.
22. Beam RC, Kunz DA, Cook CR, Carson RL, Briscoe P, and Cook JL. Three-dimensional computed tomography for diagnosis and treatment planning for a case of intermittent open-mouth jaw locking in a Persian cat. J Am Vet Med Assoc 2007;230:59-63.
23. Headrick J, Cook JL, Helphrey M, Crouch DT, Fox DB, Schultz L, Cook CR, Kunkel J. A novel radiographic method to facilitate measurement of the tibial plateau angle in dogs. A prospective clinical study. Vet Comp Orthop Traumatol 2007;20:24-28.
24. Thieman KM, Tomlinson JL, Fox DB, Cook CR, and Cook JL. Effect of meniscal release on rate of subsequent meniscal tears and owner-assessed outcome in dogs with cruciate disease treated with tibial plateau leveling osteotomy. Vet Surg 2006;35:705-710.
25. Fox DB, Cook JL, Kuroki K, Cockrell M. Effects of dynamic compressive load on collagen-based scaffolds seeded with fibroblast-like synoviocytes. Tissue Eng 2006;12:1527-1537.
26. Hughes MS, Kazmier P, Burd TA, Anglen J, Stoker AM, Kuroki K, Carson WL, and Cook JL. Enhanced fracture and soft tissue healing by means of anabolic dietary supplementation. J Bone Joint Surgery 2006;88A:2386-2394.
27. Stoker AM, Cook JL, Kuroki K, Fox DB. Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs. J Ortho Surg Res 2006;1:8.
28. Greenberg DD, Stoker AM, Kane S, Cockrell M, and Cook JL. Biochemical effects of two different hyaluronic acid products in a co-culture model of osteoarthritis. Osteoarthritis and Cartilage 2006;14:814-822.
29. Cook JL, Fox DB, Malaviya P, Tomlinson JL, Farr J, Kuroki K, Cook CR. Evaluation of small intestinal submucosa grafts for meniscal regeneration in a clinically-relevant posterior meniscectomy model in dogs. J Knee Surg 2006;19:159-167.
30. Fox DB, Tomlinson JL, Cook JL, Breshears LM. Principles of uniapical and biapical radial deformity correction using dome osteotomies and the center of rotation of angulation methodology in dogs. Vet Surg 2006;35:67-77.
31. Cook JL, Fox DB, Malaviya P, Tomlinson JL, Kuroki K, Cook CR, Kladakis S. Long-term evaluation of treatment of large meniscal defects using small intestinal submucosa in a dog model. Am J Sports Med 2006; 34:32-42.
32. Garcia-Seco E, Wilson DA, Cook JL, Kuroki K, Kreeger JM, Keegan KG. Measurement of articular cartilage stiffness of the femoropatellar, tarsocrural, and metatarsophalangeal joints in horses and comparison with biochemical data. Vet Surg 2005;34:571-578.
33. Cook JL, Renfro DC, Tomlinson JL, Sorensen JE. Measurement of angles of abduction for diagnosis of shoulder instability in dogs using goniometry and digital image analysis. Vet Surg 2005;34:463-468.
34. Cook JL, Tomlinson JL, Fox DB, Kenter K, Cook CR. Treatment of dogs diagnosed with medial shoulder instability using radiofrequency-induced thermal capsulorrhaphy. Vet Surg 2005;34:469-475.
35. Robb JL, Cook JL, Carson W. In vitro evaluation of screws and suture anchors in metaphyseal bone of the canine tibia. Vet Surg 2005;34:499-508.
36. Mahn MM, Cook JL, Cook CR, Balke MT. Arthroscopic verification of ultrasonographic diagnosis of meniscal pathology in dogs. Vet Surg 2005;34:318-323.
37. Ota J, Cook JL, Lewis DD, Tomlinson JL, Fox DB, Cook CR, Schultz LG, Brumitt J. Short-term aseptic loosening of the femoral component in canine total hip replacement: Effects of cementing technique on cement mantle grade. Vet Surg 2005;34:345-352.
38. Curry SL, Cogar SM, Cook JL.  Non-steroidal anti-inflammatory drugs: A review. J Am Anim Hosp Assoc 2005;41:298-309.
39. Kuroki K, Cook JL, Stoker AM, Turnquist SE, Kreeger JM, Tomlinson JL. Characterizing osteochondrosis in the dog: Potential roles for matrix metalloproteinases and mechanical load in pathogenesis and disease progression. Osteoarthritis and Cartilage, 2005; 13: 225-234.
40. Cook JL.  The current status of treatment for large meniscal defects. Clin Orthop Rel Res 2005;495:88-95.
41. Kuroki K, Stoker AM, Cook JL. Effects of pro-inflammatory cytokines on canine articular chondrocytes in three-dimensional culture. Am J Vet Res 2005; 66:1187-1196.
42. Holsworth IG, Schulz KS, Kass PH, Scherrer WE, Beale BS, Cook JL, Hornoff WJ. Comparison of arthroscopic and radiographic findings in hip joints of juvenile dogs with hip dysplasia. J Am Vet Med Assoc 2005;227:1091-1094.
43. Cook JL, Kenter K, Fox DB. Arthroscopic biceps tenodesis: Technique and results in six dogs. J Am Anim Hosp Assoc 2005; 41:121-127.
44. Luther JF, Cook JL, Stoll MR. Arthroscopic exploration and biopsy for diagnosis of septic arthritis and osteomyelitis of the coxofemoral joint in a dog. Vet Comp Ortho Trauma 2005; 18:47-51.
45. Headrick JF, Fox DB, Cook CR, Tomlinson JL, Cook JL. What is your diagnosis? Fracture of the polymethyl methacrylate hip prosthesis and loosening of the femoral component. J Am Vet Med Assoc 2005;226:1805-1806.
46. Ray A, Kumar D, Shakya A, Brown CR, Cook JL, Ray BK.  Serum amyloid A-activating factor-1 (SAF-1) transgenic mice are prone to develop a severe form of inflammation-induced arthritis. J Immunol 2004; 173: 4684-4691.
47. Kuroki K, Cook JL, Kreeger JM. Effects of tissue inhibitor of metalloproteinases on canine chondrocytes cultured in vitro with tumor necrosis factor-α. Am J Vet Res 2004; 65:1611-1615.
48. Syrcle JA, Cook JL. Use of a titanium plate for novel fixation of a distal radial fracture in an Italian Greyhound. Vet Comp Ortho Trauma 2004; 17: 121-124.
49. Cook JL, Kuroki K, Kenter K, Marberry K, Brawner T, Geiger T, Jayabalan P, Bal BS. Bipolar and monopolar radiofrequency treatment of osteoarthritic knee articular cartilage: Acute and temporal effects on cartilage compressive stiffness, permeability, cell synthesis, and extracellular matrix composition. J Knee Surg 2004;17:99-108.
50. Cook JL, Marberry K, Kuroki K, Kenter K.  Cellular, biochemical, and histologic effects of bipolar radiofrequency treatment of canine articular cartilage. Am J Vet Res 2004;65:604-609.
51. Fox DB, Cook JL, Arnoczky SP, Tomlinson JL, Kuroki K, Kreeger JM, Malaviya P.  Fibrochondrogenesis of free intra-articular small intestinal submucosa scaffolds. Tissue Engineering 2004;9:129-137.
52. Jehn CT, Perzak DE, Cook JL, Johnston SA, Todhunter RJ, Budsberg SC.  Usefulness, completeness, and accuracy of Web sites providing information on osteoarthritis in dogs. J Am Vet Med Assoc 2003;223:1272-1275.
53. Essman SC, Lattimer JL, Cook JL, Turnquist S, Kuroki K. Effects of 153Sm-ethylenediaminetetramethylene phosphonate on physeal and articular cartilage in juvenile rabbits. J Nucl Med 2003;44:1510-1515. **Alavi-Mendell Award**
54. Kuroki K, Cook JL, Kreeger JM, Tomlinson JL. The effects of TIMP-1 and -2 on canine chondrocytes cultured in three-dimensional agarose culture system. Osteoarthritis and Cartilage 2003; 11:625-635.
55. Hancock R, Cook JL, Tomlinson JL.  Distraction osteogenesis for treatment of premature physeal closure and shortening of the third and fourth metatarsals of a dog.  J Am Anim Hosp Assoc 2003;39:97-103.
56. Cook JL, Williams N, Kreeger JM, Peacock JT, Tomlinson JL. Biocompatibility of three-dimensional chondrocyte grafts in large tibial defects of rabbits. Am J Vet Res 2003; 64:12-20.
57. Ray A, Kuroki K, Cook JL, Bal BS, Kenter K, Aust G, Ray BK. Induction of matrix metalloproteinase-1 gene expression is regulated by inflammation-responsive transcription factor Serum Amyloid A-Activating Factor-1 in osteoarthritis. Arthritis and Rheumatism 2003;48:134-145.
58. Beatty MW, Ojha AK, Cook JL, Alberts LR, Mahanna GK, Iwasaki LR, Nickel JC.  Small intestinal submucosa versus salt-extracted polyglycolic acid-poly-L-lactic acid: A comparison of neocartilage formed in two scaffold materials. Tissue Engineering 2002;8:955-968.
59. Kuroki K, Cook JL, Kreeger JM.  Mechanisms of action and potential uses of hyaluronan in dogs with osteoarthritis. J Am Vet Med Assoc 2002;221:944-950.
60. Kuroki K, Kreeger JM, Cook JL, Tomlinson JL, Johnson GC, Pace LW, Turnquist SE, Turk JR, Ramos JA, Miller AM. Immunohistochemical analysis of matrix metalloproteinase-1, -3, and –13 in naturally occurring cartilaginous tumors of dogs. Am J Vet Res 2002;63:1285-1291.
61. Dvorak L, Cook JL, Kreeger JM, Kuroki K, Tomlinson JL. Effects of carprofen and dexamethasone on canine chondrocytes in a three-dimensional culture model of osteoarthritis. Am J Vet Res 2002;63:1363-1369.
62. Stoll M, Cook JL, Pope ER, Carson WL, Kreeger JM. The use of porcine small intestinal submucosa as a biomaterial for perineal herniorrhaphy in the dog. Vet Surg 2002;31:379-390.
63. Priddy N, Cook JL, Dodam JR, Kreeger JM, Tomlinson JL, Kuroki K. Effects of an opioid receptor agonist and antagonist on cytokine-stimulated canine articular chondrocytes in three-dimensional culture. Vet Comp Orthop Trauma 2002;15:72-77.
64. Fox DB, Cook JL, Kreeger JM, Beissenherz M, Henry CJ. Canine synovial sarcoma: A retrospective assessment of described prognostic criteria in 16 cases (1994-1999). J Am Anim Hosp Assoc 2002; 38:347-355.
65. Tomlinson JL, Cook JL. Effects of degree of acetabular rotation after triple pelvic osteotomy on the position of the femoral head in relationship to the acetabulum. Vet Surg 2002;31:398-403.
66. Noone TJ, Millis DL, Korvick DL, Athanasiou K, Cook JL, Kuroki K, Buonomo F. Influence of canine recombinant somatotropin hormone on biomechanical and biochemical properties of the medial meniscus in stifles with altered stability. Am J Vet Res 2002;63:419-426.
67. Kuroki K, Cook JL, Tomlinson JL, Kreeger JM.  In vitro characterization of chondrocytes isolated from naturally occurring osteochondrosis lesions of the humeral head of dogs. Am J Vet Res 2002;63:186-193.
68. Fox DB, Cook JL. Synovial fluid markers of osteoarthritis in dogs. J Am Vet Med Assoc 2001; 219 (6):756-761.
69. Tomlinson JL, Cook JL, Kuroki K, Kreeger JM, Anderson MA. Biochemical characterization of cartilage affected by osteochondritis dissecans in the humeral head of dogs. Am J Vet Res 2001; 62(6):876-881.
70. Priddy NH, Cook JL, Kreeger JM, Tomlinson JL, Steffen DJ. Effects of ascorbate and medium type on chondrocytes in three-dimensional tissue culture. Vet Therapeutics 2001;2(1):70-77.
71. Cook JL, Tomlinson JL, Arnoczky SP, Fox DB, Cook CR, Kreeger JM. Kinetic study of the replacement of porcine small intestinal submucosa grafts and the regeneration of meniscal-like tissue in large avascular meniscal defects in dogs. Tissue Engineering, 2001;7(3): 321-334.
72. Cook JL, Tomlinson JL, Stoll MR, Crouch DT, Priddy NH. Arthroscopic removal and curettage of osteochondrosis lesions on the lateral and medial trochlear ridges of the talus in two dogs. J Am Anim Hosp Assoc 2001;37:75-80.
73. Crouch DT, Cook JL, Lewis DD, Kreeger JM, Tomlinson JL. Determination of collagen types II and X in surgically excised fragmented medial coronoid processes of dogs. Vet Comp Orthop Trauma 2000;13(4):178-184.
74. Cook JL, Anderson CC, Kreeger JM, Tomlinson JL. In vitro osteoarthritis model using IL-1ß in three-dimensional chondrocyte culture. Am J Vet Res 2000;61(7):766-770.
75. Anderson CC, Cook JL, Kreeger JM, Tomlinson JL, Wagner-Mann CC. In vitro effects of glucosamine and acetylsalicylate on canine chondrocytes in three-dimensional culture. Am J Vet Res 1999;60(12):1546-1551.
76. Cook JL, Tomlinson JL, Reed A. Fluoroscopically-guided closed reduction and internal fixation of lateral humeral condylar fractures: Technique and results in 10 dogs. Vet Surg 1999;28(5):315-321.
77. Cook JL, Tomlinson JL, Kreeger JM, Cook CR. Induction of meniscal regeneration in dogs using a novel biomaterial. Am J Sports Med 1999;27(5):658-665.
78. Tomlinson JL, Cook JL, Payne JT, Anderson CC, Johnson JC.  Closed reduction and lag screw fixation of sacroiliac luxations and fractures. Vet Surg 1999;28:188-93.
79. Cook JL, Turk JR, Pope ER, Jordan RC. Infantile dermoid-type fibromatosis in an Akita puppy. J Am Anim Hosp Assoc 1998;34(4):291-4.
80. Cook JL, Turk JR, Tomlinson JL, Corwin LA, Shaw DC. Fibrosarcoma in the distal radius and carpus of a Persian cat. J Am Anim Hosp Assoc 1998;34(1):31-3.
81. Cook JL, Kreeger JM, Payne JT, Tomlinson JL. Effects of EGF, FGF, and PDGF on canine chondrocytes in three-dimensional culture. Vet Comp Orthop Traumatol 1997;10(4):21-3.
82. Cook JL, Cook CR, Tomlinson JL, Millis DL, Starost M, Albrecht MA, Payne JT. Scapular fractures in dogs: Epidemiology, classification, and concurrent injuries in 105 cases (1988-1994). J Am Anim Hosp Assoc 1997;33(6):528-32.
83. Cook JL, Kreeger JM, Payne JT, Tomlinson JL. Three-dimensional culture of canine articular chondrocytes on multiple transplantable substrates. Am J Vet Res 1997;58(4):419-424.
84. Cook JL, Jordan RC. What is your diagnosis? (Retinal dysplasia and developmental skeletal abnormalities in a labrador). J Am Vet Med Assoc 1997;210(3):329-30.
85. Cook JL, Tomlinson JL, Constantinescu GM. Pathophysiology, diagnosis, and treatment of canine hip dysplasia. Comp Contin Educ Pract Vet 1996;18(8):853-67.
86. Cook JL, Albrecht MA, Gores BR. What is your diagnosis? (Peritoneopericardial herniation of the liver with secondary chylous effusion in a cat). J Am Vet Med Assoc 1996;208(12):1975-6.
87. Cook JL, Gross MM. What is your diagnosis? (Nutritional secondary hyperparathyroidism with an associated vertebral fracture in a Persian kitten). J Am Vet Med Assoc 1996;208(7):1019-20.
88. Cook JL, Philibert JC. What is your diagnosis? (Colonic perforation associated with pelvic fractures in a dog). J Am Vet Med Assoc 1995;207(8):1033-4.
89. Cook JL, Huss BT, Johnson GC. Periosteal osteosarcoma in the long head of the triceps in a dog. J Am Anim Hosp Assoc 1995;31(4):317-20.
90. Cook JL, Aronson E. What is your diagnosis? (OCD of the lateral trochlear ridge of the talus.) J Am Vet Med Assoc 1995;206(12):1871-2.
91. Anderson MA, Cook JL. What is your diagnosis? (Bilateral femoral neck fractures). J Am Vet Med Assoc 1994;205(10):1399-1400.

Contact Information:

Comparative Orthopaedic Laboratory
University of Missouri
379 East Campus Drive
Columbia, MO 65211
(573) 884-0603
E-mail: cookjl@missouri.edu